Article
A standardised evaluation of pre-surgical imaging of the corticospinal tract: Where to place the seed ROI?
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Authors
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Julian Rathert
- Klinik für Neurochirurgie, Helios Klinikum Erfurt, Deutschland
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Elke Hattingen
- Institut für Neuroradiologie, Klinikum der Goethe-Universität Frankfurt, Deutschland
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Alina Jurcoane
- Institut für Neuroradiologie, Klinikum der Goethe-Universität Frankfurt, Deutschland
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Friedhelm E. Zanella
- Institut für Neuroradiologie, Klinikum der Goethe-Universität Frankfurt, Deutschland
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Volker Seifert
- Klinik und Poliklinik für Neurochirurgie, Klinikum der Goethe-Universität Frankfurt, Deutschland
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Thomas Gasser
- Klinik und Poliklinik für Neurochirurgie, Klinikum der Goethe-Universität Frankfurt, Deutschland
| Published: | September 16, 2010 |
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Outline
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Objective: In subcortical glioma surgery, preservation of fibers originating in the precentral gyrus is still challenging. Preoperative DTI based tractography allows an approximation of the course of fibers. The aim of the study was to compare the different approaches of pre-operative diffusion-tensor-imaging-based fibre tracking (FT) of the corticospinal tract (CST) focusing on the positioning of the seeding region of interest (seed ROI).
Methods: Thirty-nine patients with brain lesions in the vicinity of the CST were evaluated pre-operatively. Imaging comprised a 3D T1-weighted sequence, functional magnetic resonance imaging (fMRI), and a diffusion-weighted sequence for diffusion tensor (DT) tractography. DT tractography was performed with two different procedures to track the corticospinal fibres: one downwards and one upwards. Downward FT was started with the seed ROI in the pre-central gyrus subjacent to the maximal fMRI activity while for the upward FT seed ROI was placed in the cerebral peduncle. In 16 patients, tracking results were individually compared with the unaffected contralateral hemisphere. The resulting bundles were confirmed by anatomical landmarks and segmented three-dimensionally (iPlan 2.5Cranial, BrainLab®, Feldkirchen). Results were correlated with fractional anisotropy (FA) values and other factors potentially influencing fibre tracking results.
Results: On the side of the space-occupying lesion, downward FT yielded more positive tracking results (tracked fibres >0) than the upward FT. On both the affected and the unaffected side, downward FT reconstructed fewer fibres than upward FT. For neither method did the tracking results (number and volume of fibres) correlate with FA values or with other clinical data. FA values for tracts ipsilateral to the lesion correlated with age and lesion entity.
Conclusions: We conclude that the sequence of ROI positioning influences significantly the tracking results. Upward FT may fail to track fibres, whereas the successful tracking results may be superior to downward FT. Hence, upward FT of the CST should be preferred in patients with space-occupying lesions. Downward FT should be performed if upward FT fails.
