gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

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The role of CT perfusion studies in the evaluation of patients with NPH: A pilot study

Die Bedeutung der CT-Perfusion bei der Evaluierung von Patienten mit NPH: Eine Pilotstudie

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  • corresponding author C. Müller - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Greifswald
  • J. U. Müller - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Greifswald
  • M. Kirsch - Institut für Diagnostische Radiologie und Neuroradiologie, Universitätsklinikum Greifswald
  • S. Langner - Institut für Diagnostische Radiologie und Neuroradiologie, Universitätsklinikum Greifswald
  • M. J. Fritsch - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Greifswald
  • H. W. S. Schroeder - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Greifswald

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocP 107

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2007/07dgnc362.shtml

Published: April 11, 2007
Published with erratum: January 8, 2008

© 2007 Müller et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Several studies have evaluated cerebral perfusion and hemodynamic parameters (flow velocity/TCD, CBF/PET, rCBF/SPECT, 3D-perfusion/MRI) in regard to their role as predictors of successful shunt surgery in patients with normal pressure hydrocephalus. In a prospective pilot-study we evaluated CT perfusion as an additional method for the evaluation of cerebral perfusion before and after shunt surgery in patients with NPH.

Methods: We examined 12 consecutive patients with typical features of NPH. The patients underwent CT perfusion study prior to shunt surgery and on day 7 following shunt surgery. The pre- and postop studies were evaluated by two independent neuroradiologists in regard to perfusion parameters (regional perfusion deficits, time to peak, mismatching). All patients benefited from the shunting procedure at the one-year follow-up.

Results: In the evaluation of the CT-perfusion studies, no difference was found between pre- and post shunt images. All studies (preoperative as well as postoperative) were read as normal within limits. Minor ischemic deficits seen on CT perfusion have been known and documented in previous examinations. Neither change nor improvement could be seen comparing pre- and postoperative scans.

Conclusions: We conclude that CT perfusion studies do not present a valid method for the evaluation of cerebral perfusion in patients undergoing shunt surgery for NPH. The method has no role in predicting possible successful candidates and also no role in comparing pre- and postoperative brain perfusion.

Outline

Erratum

The name of the first author "C. Müller" was erroneously omitted in the initial publication.