gms | German Medical Science

GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

Deutsche Gesellschaft für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie e.V. (DGHNOKHC)

ISSN 1865-1038

Trends in antibiotic treatment of acute sinusitis in the last decade – evidence based study

Poster

  • corresponding author Ilhana Setic - ENT clinc, clinical center university of sarajevo, Sarajevo, Bosnia and Herzegovina
  • Jasminka Alagic-Smailbegovic - ENT Clinic Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
  • Mersiha Becirovic - ENT Clinic Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2011;7:Doc16

DOI: 10.3205/cpo000605, URN: urn:nbn:de:0183-cpo0006059

Published: April 14, 2011

© 2011 Setic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Abstract

Background: antibiotics are basic in treatment of acute bacterial sinus infection.

Aim: which antibiotic classes are the most common used in clinical trials in treating acute bacterial sinusitis, according to EPOS 2007. guidelines.

Data sources: relevant English-language articles identified in the PubMed Central and MEDLINE databases.

Study selection: articles about antibiotic treatment of acute sinusitis in adults (19+years), all clinical trials, meta-analysis, practice guidelines and randomized controlled trials published in the last ten years. There were 91 articles, and 53 of them evaluated.

Data extraction: articles about complications, no-bacterial and chronic sinusitis, case-reports, surgical treatments.

Results: There are totally 15.456 patients in 53 clinical trials. Antibiotic-classes in evaluated trials: penicillin-gruop (49.06%), quinolons (35.86%), macrolids and ketolids (32.07%), cephalosporins (15.09%), carbapenems (3.77%). In relation to total number of treated patients, the most common antibiotics in observed period are from penicillin group (45%). Other antibiotics: quinolons 21.07%, telithoromycin 10.51%, cephalosporins 9.95%, macrolids 9.2%, and carbapenems in 4.24% treated patients. Short-course of antibiotic treatment (less than 7 days) confirmed as safe and effective in 80.7% trials.

Conclusion: Although is the amoxicillin and amoxicillin/clavulanate still the most common antibiotic in treatment of acute sinusitis, recent clinical trials are more based on second-line antibiotics, more in single-dose and in short-course treatment.