gms | German Medical Science

International Conference on SARS - one year after the (first) outbreak

08. - 11.05.2004, Lübeck

The mannose-specific plant lectins from Cymbidium hybrid, Listera ovata, Hippeastrum hybrid and Morus Nigra and the (N-acetylglucosamine)n-specific plant lectins from Urtica dioica and Nicotian tabacum are potent inhibitors of SARS coronavirus in vitro

Poster

  • corresponding author presenting/speaker Els Keyaerts - Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
  • Leen Vijgen - Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
  • Els van Damme - Department of Molecular Biotechnology, RUGent, Gent, Belgium
  • Willy Peumans - Department of Molecular Biotechnology, RUGent, Gent, Belgium
  • Erik de Clercq - Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
  • Jan Balzarini - Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
  • Marc van Ranst - Rega Institute for Medical Research, University of Leuven, Leuven, Belgium; U.Z. Leuven, Leuven, Belgium

International Conference on SARS - one year after the (first) outbreak. Lübeck, 08.-11.05.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04sarsP9.04

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/sars2004/04sars126.shtml

Veröffentlicht: 26. Mai 2004

© 2004 Keyaerts et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

In this study, 4 mannose(Man)- and two N-acetylglucosamine (GlcNAc)n-specific plant agglutinins (lectins) were evaluated for their antiviral activity against the SARS coronavirus (SARS CoV) Frankfurt 1 strain in vitro. The mannose-specific agglutinins from the orchid species Cymbidium hybrid (CA) and Listera ovata (LOA), the mannose-specific agglutinins from Hippeastrum hybrid (Amaryllis, HHA) and Morus Nigra (black mulberry tree, MornigaM) were highly inhibitory to SARS CoV in Vero E6 cells. Also, (GlcNAc)n-specific agglutinins from Urtica dioica (stinging nettle, UDA) and Nicotian tabacum (Tabacco plant, Nictaba) were inhibitory to SARS CoV. [Tab. 1]