gms | German Medical Science

54. Jahrestagung der Norddeutschen Orthopädenvereinigung e. V.

Norddeutsche Orthopädenvereinigung

16.06. bis 18.06.2005, Hamburg

Epidural perineural injection of Orthokine conditioned autologous serum vs Triamcinolone for the treatment of lumbar radicular pain : a prospective, randomized, double blinded clinical study

Meeting Abstract

  • corresponding author C. Becker - St. Josef-Hospital, University Bochum, Orthopaedic Surgery, Bochum
  • C. Becker - Bochum
  • S. Heidersdorf - Aachen
  • S. Drewlo - Bochum
  • S. Zirke de Rodriquez - Bochum
  • R. Willburger - Bochum
  • J. Krämer - Bochum

Norddeutsche Orthopädenvereinigung. 54. Jahrestagung der Norddeutschen Orthopädenvereinigung e.V.. Hamburg, 16.-18.06.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05novEP12

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Veröffentlicht: 13. Juni 2005

© 2005 Becker et al.
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Triamcinolone epidural perineural injections are established modalities in lumbar nerve root compression therapy. Here we compare effectiveness and safety of injected Orthokine autologous conditioned serum (ACS) vs Triamcinolone (5mg/10mg).


90 patients with unilateral sciatica based on signs of single lumbar nerve root compression verified by MRI. Three injections (once per week). Objective and subjective outcome assessments performed six times per patient. Follow up: six months. Needle position verified by x-ray. Oral Ibuprofen was only additional treatment/therapy inside follow up period. Subjective assessment included VAS, Oswestry score, SF36. Objective assessment performed by standardized clinical examination. Treatment effectiveness evaluated by variance analysis.


At baseline no statistically significant difference between groups. Statistically significant VAS pain reduction in all 3 groups after three months, p<0.05. Orthokine group was superior to Triam groups after 3 and 6 months. No significant difference between Triam groups. No adverse effects or complications in any group.


ACS and Triam 5mg/10mg improve radicular pain and other functional parameters vs pretreatment values. The advantage of ACS vs steroid group was statistically significant. Orthokine-conditioned serum may display a regenerative effect that could explain the long term efficacy.