gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Microalbuminuria in hypertensives and the body mass index –

Meeting Abstract

  • S. Lüders - Medizinische Klinik Cloppenburg (Cloppenburg, D)
  • A. Kulschewska - Medizinische Klinik Cloppenburg (Cloppenburg, D)
  • S. Lüders - St. Josefs-Hospital
  • F. Hammersen - St. Josefs-Hospital
  • C. Züchner - St. Josefs-Hospital
  • U. Veneklaas - St. Josefs-Hospital
  • G. Schrandt - St. Josefs-Hospital
  • A. Klaus - St. Josefs-Hospital
  • J. Schrader - St. Josefs-Hospital
  • M. Schnieders - INFO-GmbH-Institue for Hypertension and Cardiovascular Research
  • A. Gansz - INFO-GmbH-Institue for Hypertension and Cardiovascular Research

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP186

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2005/05hoch186.shtml

Veröffentlicht: 8. August 2006

© 2006 Lüders et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background: In a long-term study (mean observation time 42.5 months) with non-diabetic hypertensives microalbuminuria (MAU) could be shown to be an independent risk factor for cardio- and cerebrovascular events. All patients received ramipril as basic antihypertensive treatment.

The correlation between MAU as risk factor and the body mass index (bmi) was investigated in a subgroup analysis.

Methods: 3518 patients (pts) were assigned to groups according to bmi as normal weight (wt), pre-adipose, or adipose (2000 WHO-definition: normal weight: bmi=18.5-24.9, pre-adipose: 25-29.9, adipose: >= 30).

End point rates (combined cardio-,cerebrovascular events and total mortality) were analysed for present or missing microalbuminuria at the start of the observation period.

Results: group distribution: normal wt: n=705 (20.0%), pre-adipose: n=1734 (49.3%), adipose: n=1079 (30.7%). At the start of the observation period, pts who did not have a normal wt showed higher incidence of pathological proteinuria than those with normal wt (38.0% vs. 33.8%).

Overall, 1188 pts showed MAU: normal wt 224 (31.8 %), pre-adipose 587 (33.9%), adipose 377 (34.9%). The event rate without/with MAU was: in the normal wt pts 7.0 / 11.6%, in the pre-adipose group 5.6 /12.6 % and for adipose pts 9.6 / 10.9%.

Independantly of bmi-group all pts had a higher event rate if they did have MAU. Normal wt pts with MAU had a higher event rate than adipose pts without MAU.

Conclusion: In all bmi-groups, the presence of microalbuminuria indicates an increase in cardiovascular risk. The prognosis for normal wt hypertensives with MAU is worse than that for adipose hypertensives without MAU.