gms | German Medical Science

28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

24. bis 27.11.2004, Hannover

High protein nutrition during pregnancy and lactation programs blood pressure and body weigth of the offspring in a gender dependent manner

Meeting Abstract (Hypertonie 2004)

  • C. Thöne-Reineke - Center for Cardiovascular Research (CCR) (Berlin, D)
  • M. Dorn - Center for Cardiovascular Research (CCR) (Berlin, D)
  • S. Klaus - German Institute of Human Nutrition (Bergholz-Rehbrücke, D)
  • K. Simon - Center for Cardiovascular Research (CCR) (Berlin, D)
  • T. Pfab - Center for Cardiovascular Research (CCR) (Berlin, D)
  • M. Godes - Center for Cardiovascular Research (CCR) (Berlin, D)
  • T. Unger - Center for Cardiovascular Research (CCR) (Berlin, D)
  • B. Hocher - Center for Cardiovascular Research (CCR) (Berlin, D)

Hypertonie 2004. 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Hannover, 24.-27.11.2004. Düsseldorf, Köln: German Medical Science; 2005. Doc04hochP131

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Veröffentlicht: 10. August 2005

© 2005 Thöne-Reineke et al.
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We examined the influence of a high protein diet during pregnancy and lactation on the outcome of the F1 generation. Female Wistar rats were divided into 2 groups soon after became pregnant and fed at adequate protein diet (20% protein NP) and high protein diet (40% protein HP) throughout pregnancy and lactation. At weaning, pups were fed with standard diet (altromin 1321). Over the period of the experiment (22 weeks) the animals were physiological characterized by measurement of bodyweight every week, food intake twice a week, body composition with two and three weeks after birth, energy expenditure with three month, kidney function every 8 weeks, measurement of bloodpressure every 8 weeks, glucose tolerance test with 22 weeks and histomorphological analyses of the kidneys and measurement of fat pat at the end of the experiment.

There are no differences in birth weight between the pups of NP and HP feeded mothers. After 8 weeks the female progeny of HP feeded mothers become a significant higher bodyweight in comparison to the females of NP feeded dams (211,9 g NP females vs.220,2 HP females p<0,03).

A similar effect was observed at the end of the experiment were the relative weight of ovarial fat pats in the females were significant higher. Furthermore these females have higher urine excretion and relative kidney weight.

The males pups of HP feeded mothers develop significant higher blood pressure (BP 126 mmHg NP-males vs. 134 mmHg HP-males p<0,001)after 8 weeks and the kidneys shows glomerulosclerosis in comparison to the progeny of NP feeded mothers (2,5 NP-males vs 2,7 HP-males p<0,05). These results indicate that in utero exposure to a high protein level reprograms body weight and kidney function in females and blood pressure and progression of kidney failure in males.

In Memoriam to Maren Dorn.