gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Large and small artery compliance is linked to endothelium function in humans

Die Compliance der Gefäße hängt mit der Endothelfunktion des Menschen zusammen

Meeting Abstract (Hypertonie 2003)

  • presenting/speaker T.K. Schwarz - (Nürnberg, D)
  • M.P. Schneider - (Nürnberg, D)
  • B.M.W. Schmidt - (Nürnberg, D)
  • S. John - (Nürnberg, D)
  • R.E. Schmieder - (Nürnberg, D)

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP56

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2003/03hoch156.shtml

Veröffentlicht: 11. November 2004

© 2004 Schwarz et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background

Early atherosclerotic changes are characterized by an impaired endothelium function, which results in either reduced basal nitric oxide (NO) activity or attenuated NO-stimulation. In the current study we examined whether endothelial NO-activity is related with arterial compliance in the large (C1) and small vessels (C2).

Methods

We examined 32 patients with hypercholesterolemia (LDL ³ 130 mg/dl) at baseline and after 14 days of statin therapy. Changes in forearm blood flow (FBF) were measured by strain gauge plethysmography in response to increasing doses of intraarterially (i.a.) given acetylecholine (12 and 48µg/min) and i.a. L-NMMA (4 and 8µmol/min). C1 and C2 were detected through waveform analysis with a calibrated tonometer (HDI/PulseWaveÓ system).

Results

Baseline FBF increased at acetylcholine (ACH) 12 µg/min to 325 ± 217% and at ACH 48µg/min to 418 ± 281% (p<0.01). Infusion of L-NMMA 4 and 8 µmol/min produced a reduction in FBF of 32 ± 11 and 41 ± 9%, respectively (p<0.001). Of note, C1 shows a strong correlation with the relative (-0.49, p=0.005) and absolute (-0.55, p=0.001) increase of FBF at ACH 12µg/min. The correlation coefficients for ACH 48µg/min were similar, -0.43 (p=0.014) and -0.49 (p=0.004) respectively. C2 shows a correlation with ACH 12µg/min absolute (-0.412, p=0.019) and relative -0.446, (p=0.011) but not with 48µg/min. After 14 days of statin therapy the change of the response to L-NMMA 4 µg/min was linked to changes of C1 (-0.505, p=0.008).

Conclusion

Our results showed strong relation between invasive measurement of the endothelial NO-activity response to vasoactive substances and the non-invasive determined vascular compliance. Thus, alterations in vascular compliance of small or large arteries are linked to impaired endothelium function thereby offering the possibility to estimate the impairment of endothelial dysfunction by measurement of the peripheral vascular compliance.