Artikel
Multidisciplinary management of congenital neuroblastoma in infants
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Veröffentlicht: | 4. April 2012 |
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Gliederung
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Introduction: Authors present management of a rare malignant tumour of the neck: diagnostic, surgical and oncological treatment of neuroblastoma in 2 infants.
Methods: In both 6 months old infants a right neck lump developed – multiple tumour and lymph nodes. On the basis of clinical findings, quick progression of the tumour and MRI scans neck malignancy was suspected and surgical resection of the tumour was indicated (neck dissection). Pathological findings established neuroblastoma in both infants, so chemotherapy was started at the Department of Pediatry (SIOP, neuroblastoma protocol).
Results: In the first case a metastatic lesion was observed on the left neck 2 months later as well. Neck dissection (mRND) was performed on the left too and chemotharapy was administered. There is no recurerrence since 13 months.
In the other infant resection of the right neck malignancy was performed (mRND) and chemotherapy was given. Since 12 months there is no sign of recurrence. This infant was also treated with chronic severe dysphagia, muscular hypotony and somato-mental disorder, PEG was inserted for feeding.
Their postoperative MRI showed no recurrence.
Conclusions: Prognosis of the neck neuroblastoma in infants (under age of 1 year) after early detection and treatment is good, but age, pathological finding and genetic (N-myc expression) have an impact on it.