gms | German Medical Science

Kongress Medizin und Gesellschaft 2007

17. bis 21.09.2007, Augsburg

Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren

Meeting Abstract

  • Gabriele Nagel - Institute of Epidemiology, Ulm University, Ulm
  • Wolfgang Koenig - Department of Internal Medicine II Cardiology, Ulm University Medical Center, Ulm
  • Kilian Rapp - Institute of Epidemiology, Ulm University, Ulm
  • Martin Wabitisch - Department of Paediatrics, Ulm University Medical Center, Ulm
  • Iris Zoellner - Department of Epidemiology and Health Reporting Baden-Württemberg, State Health Office, Stuttgart
  • Stephan K Weiland - Institute of Epidemiology, Ulm University, Ulm

Kongress Medizin und Gesellschaft 2007. Augsburg, 17.-21.09.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07gmds287

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gmds2007/07gmds287.shtml

Veröffentlicht: 6. September 2007

© 2007 Nagel et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background: There is growing evidence for an association between obesity and asthma, but little is known about the mechanisms. We investigated the associations of plasma leptin and adiponectin concentrations with asthma and allergies in children.

Methods: A population-based cross-sectional study was carried out. Among 462 children aged 10 years plasma leptin and adiponectin concentrations were measured. Information on disease symptoms and diagnosis was collected by parental questioning. Multivariate logistic regression models were used to analyze the data.

Results: High leptin levels (≥90th percentile) were associated with increased lifetime prevalence of asthma (OR: 3.76; 95%-CI: 1.42-9.92). The relationship was particularly strong with non-atopic asthma (OR: 5.51; 95%-CI: 1.99-17.51). No associations were observed between plasma leptin levels and hay fever, rhinoconjunctivitis or eczema.

Low adiponectin levels (≤ 10th percentile) were associated with increased prevalence of both symptoms of atopic dermatitis (OR: 3.23; 95%-CI: 1.28-7.76) and eczema ever (OR: 2.35; 95%-CI: 1.13-4.89). In girls and non-atopic children, stronger associations for both leptin and adiponectin levels with asthma than in the comparison groups were observed.

Conclusion: These results suggest that adipokines may contribute to increased asthma and allergy risk in obese subjects. Stronger associations among girls and with non-atopic asthma may indicate diverse pathological mechanisms.

†Stephan K. Weiland, head of the Institute of Epidemiology, Ulm University, died completely unexpected on March 19, 2007. He will live in our memories as a warm-hearted, friendly and always helpful human being and as a great scientist.