gms | German Medical Science

10. Jahrestagung der GAA Gesellschaft für Arzneimittelforschung und Arzneimittelepidemiologie

16. bis 17.10.2003, Bonn

Drug utilisation review and detection of adverse drug reactions (ADRs) on paediatric wards

Medikamentöse Therapie und unerwünschte Arzneimittelwirkungen auf pädiatrischen Stationen

Meeting Abstract

  • corresponding author Jacek Szymanski - Philipp Klee-Institute of Clinical Pharmacology, HELIOS Klinikum Wuppertal, Heusnerstr. 40, 42283 Wuppertal, Germany, Tel.: +49-202-896-1855
  • S.K. Goldhammer - Philipp Klee-Institute of Clinical Pharmacology, HELIOS Klinikum Wuppertal, Heusnerstr. 40, 42283 Wuppertal, Germany
  • S. Haffner - Philipp Klee-Institute of Clinical Pharmacology, HELIOS Klinikum Wuppertal, Heusnerstr. 40, 42283 Wuppertal, Germany
  • S. Wirth - Philipp Klee-Institute of Clinical Pharmacology, HELIOS Klinikum Wuppertal, Heusnerstr. 40, 42283 Wuppertal, Germany
  • P.A. Thuermann - Philipp Klee-Institute of Clinical Pharmacology, HELIOS Klinikum Wuppertal, Heusnerstr. 40, 42283 Wuppertal, Germany

Gesellschaft für Arzneimittelanwendungsforschung u. Arzneimittelepidemiologie (GAA) e.V.. 10. Jahrestagung der Gesellschaft für Arzneimittelforschung und Arzneimittelepidemiologie (GAA) e.V.. Bonn, 16.-17.10.2003. Düsseldorf, Köln: German Medical Science; 2003. Doc03gaa22

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gaa2003/03gaa22.shtml

Veröffentlicht: 16. Oktober 2003

© 2003 Szymanski et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background and Aim

In a previous study we observed ADRs in 13.8 % of hospitalised children, 2.5% of children were hospitalised because of an ADR. Antibiotics were the most frequently ADR-associated drugs predominantly causing gastro-intestinal symptoms. Aim of the current study: Analysis of the documented medication prescribed for all hospitalised children with the diagnoses "respiratory infections" and "epilepsy" using pre-specified definitions of ADRs and standardisation of methods.

Material and Method

Data collection between 01.03.2003 and 25.05.2003 on 2 general paediatric wards and the paediatric intensive care unit at Helios Klinikum Wuppertal (Germany). ADR collection by daily ward rounds, chart review, interview of nurses and physicians, parents and patients. Documentation of the medication of all hospitalised children with respiratory diseases and epilepsy as well as all children with ADRs into an Microsoft ACCESSÒ database. Causality was evaluated by the WHO- and Naranjo-Score.

Results

715 children were admitted during the study period, 198 suffered from an airway disease (27.7%), 23 (3.2%) children had a diagnosis of epilepsy. In the total paediatric population 67 ADRs occurred in n = 41 children (5.7%). 27 of them had a respiratory illness (65.9%) and 6 children an epilepsy (14.6%). 44.8% of ADRs were mild, none was fatal. 37 of the 67 ADRs were gastro-intestinal side effects (55.2%) and 7 were CNS symptoms (10.4%).

Antibiotics were responsible for 41 ADRs (61.2%) followed by antiepileptics (13.4%).

Conclusion

In contrast to our previous study we observed a lower number of ADRs, however, a comparable spectrum of symptoms and causative drugs. The introduction of very strict definitions and the implementation of a second algorithm for causality assessment may have a major influence on the results. Antibiotics are still the major cause for ADRs in paediatrics and the indication for their prescriptions should be carefully monitored.