gms | German Medical Science

Objective: Exercise is the strongest stress to which the body is ever exposed. The body response to this stress through a set of physiological changes in its metabolic, hormonal and immunological systems.The purpose of the study was to examine the effect of 2 months endurance training on plasma immune cells and humoral responses. The immune system components are cellular or soluble which are splashed from the specific cells and have a particular operation in the particular active conditions.

Material/Methods: Eighteen active women that were college student, participated in the study. They performed selected endurance training for two months. Before and after training, blood sample were obtained. Data was analyzed using paired sample t-test. Concentration CD4, IgA and CD4/CD8 increased and CD8 decreased significantly.

Results: Means showed the mean plasma concentration of CD4, IgA and CD4/CD8 increased after 8 weeks exercise, the mean plasma concentration of CD8 decreased and IgA secretion rate did not change significantly after exercise. T-test showed IgA response was not significantly but CD4, CD8 and CD4/CD8 response were significantly (P≤0/05).

Conclusion: It has been well established that prolonged endurance exercise is associated with muscle cell damage and local inflammation. It has been hypothesized that natural auto antibodies may be used to assist macrophages in disposal of muscle cell breakdown products. It is possible that these antibody leave the circulation to carry out this same function in tissues. It was showed that endurance training may induces changes in lymphocyte subsets and CD8, CD4 function adapted in experimental group. We conclude that endurance training may result in significant alteration in T lymphocyte number, but their actual significant for immunity is seen controversially.

Key words: CD4, CD8, IgA, exercise