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44. Kongress der Deutschen Gesellschaft für Rheumatologie, 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie, 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie

31.08. - 03.09.2016, Frankfurt am Main

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Autoantibodies against CD74 – A new diagnostic marker for Spondyloarthritis (SpA)

Meeting Abstract

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  • Torsten Matthias - AESKU. Diagnostics GmbHCo KG, Wendelsheim
  • Eva Schweikhard - AESKU. Diagnostics GmbHCo KG, Wendelsheim
  • Sandra Reuter - Aesku.Kipp Institut, Wendelsheim
  • Maria Köhler - Helios Ostseeklinik Damp, Damp
  • Joachim Georgi - Ostseeklinik Damp, Abt. Innere Medizin-Rheumatologie, Ostseebad Damp
  • Niklas Baerlecken - Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover
  • Torsten Witte - Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). Frankfurt am Main, 31.08.-03.09.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocSP.18

doi: 10.3205/16dgrh103, urn:nbn:de:0183-16dgrh1036

Veröffentlicht: 29. August 2016

© 2016 Matthias et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Background: Spondyloarthritis (SpA) is a common debilitating inflammatory disorder. The pathogenesis of axial spondyloarthritis (axSpA) including ankylosing spondylitis (AS) is still largely unclear. Establishing the diagnosis is difficult, since abnormalities in X-ray develop with a latency of several years and only HLA-B27 or radiographic sacroiliitis is used as a laboratory marker yet. Hence, to prevent destructive effects early diagnosis in SpA patients is indispensable. Therefore, we evaluated antibodies to the HLA class II- antigen associated invariant chain (CD74) as a diagnostic marker of SpA.

Methods: 118 sera of axSpA patients and 200 control sera (120 blood donors, 80 non-SpA patients) were analyzed for IgA antibodies against CD74 by ELISA. All donors provided informed consent for the study, which was approved by the local ethics committee (project number 4928).

Results: SpA patients were more often male and younger. HLA-B27 status was available in 109 patients. CD74-antibodies were detected in 91 % of SpA but in only 4 % and 8 % of healthy controls and other autoimmune disease patients, respectively (p≤0.0001). Remarkably, IgA autoantibodies against CD74 had a sensitivity of 91 % and a specificity of 94 %, (likelihood ratio: LR+: 15.6, LR-: 0.09) and were even more frequent in SpA patients with short disease duration. Furthermore, IgA anti-CD74 antibodies significantly correlate with more advanced radiological sacroiliitis and reduced spinal mobility.

Conclusion: CD74 IgA antibodies were strongly associated with SpA and can be used as a new marker. Moreover, they were found to be strongly associated with the grade of sacroiliitis.