gms | German Medical Science

68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
7. Joint Meeting mit der Britischen Gesellschaft für Neurochirurgie (SBNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

14. - 17. Mai 2017, Magdeburg

Artikel

Artikel empfehlen

Altered somatosensory cortex neuronal activity in a rat model of Parkinson's disease and levodopa-induced dyskinesias

Meeting Abstract

Suche in Medline nach

  • Mesbah Alam - Department of Neurosurgery, Hannover Medical School, Hannover, Deutschland
  • Regina Rumpel - Institute of Neuroanatomy, Hannover Medical School, Hannover, Deutschland
  • Xingxing Jin - Department of Neurosurgery, Hannover Medical School, Hannover, Deutschland
  • Christof von Wrangel - Department of Neurosurgery, Charité Universitätsmedizin Berlin, Berlin, Deutschland
  • Sarah Tschirner - Institute of Neuroanatomy, Hannover Medical School, Hannover, Deutschland
  • Joachim Krauss - Department of Neurosurgery, Hannover Medical School, Hannover, Deutschland
  • Claudia Grothe - Institute of Neuroanatomy, Hannover Medical School, Hannover, Deutschland
  • Andreas Ratzka - Institute of Neuroanatomy, Hannover Medical School, Hannover, Deutschland
  • Kerstin Schwabe - Department of Neurosurgery, Hannover Medical School, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocP 082

doi: 10.3205/17dgnc645, urn:nbn:de:0183-17dgnc6456

Veröffentlicht: 9. Juni 2017

© 2017 Alam et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Several findings support the concept that sensorimotor integration is disturbed in Parkinson`s disease (PD) and in levodopa-induced dyskinesias. In PD altered neuronal connectivity activity occurs between subcortical basal ganglia (BG) and cortical circuits, where impaired somatosensory signals may influence desired motor programs.

Methods: In this study, we explored the neuronal firing activity of excitatory pyramidal cells and inhibitory interneurons in the forelimb region of the primary somatosensory cortex (S1FL-Ctx), along with its interaction with oscillatory activity of the primary motor cortex (MCtx) in 6-hydroxydopamine lesioned hemiparkinsonian (HP) and levodopa-primed dyskinetic (HP-LID) rats as compared to controls. Further, gene expression patterns of distinct markers for inhibitory GABAergic neurons were analyzed in both cortical regions.

Results: While firing frequency and burst activity of S1FL-Ctx inhibitory interneurons were reduced in HP and HP-LID rats, measures of irregularity were enhanced in pyramidal cells. Further, enhanced coherence of distinct frequency bands of the theta/alpha, high-beta, and gamma frequency, together with enhanced synchronization of pyramidal cells and interneurons with MCtx oscillatory activity were observed. While GABA level was similar, gene expression levels of interneuron and GABAergic markers in S1FL-Ctx and MCtx of HP-LID rats differed to some extent.

Conclusion: Our study shows both electrophysiological alterations and changes in gene expression in the sensorimotor cortices in a rat model of PD, which differ depending on the functional state after dopamine depletion and treatment indicating maladaptive neuroplasticity.