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66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Friendship Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

7. - 10. Juni 2015, Karlsruhe

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Diffusion tensor imaging and intraoperative motor evoked potentials in brainstem surgery: Linkage between function and structure

Meeting Abstract

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  • Nils H. Ulrich - Department of Neuroradiology, University Hospital, University of Zurich, Switzerland
  • Yuqiang Yao - Department of Neuroradiology, University Hospital, University of Zurich, Switzerland; Department of Neurosurgery, Beijing Jishuitan Hospital, China
  • Helmut Bertalanffy - International Neuroscience Institute, INI, Hannover, Germany
  • Johannes Sarnthein - Department of Neurosurgery, University Hospital, University of Zurich, Switzerland
  • Spyros S. Kollias - Department of Neuroradiology, University Hospital, University of Zurich, Switzerland

Deutsche Gesellschaft für Neurochirurgie. 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Karlsruhe, 07.-10.06.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DocMI.17.03

doi: 10.3205/15dgnc380, urn:nbn:de:0183-15dgnc3806

Veröffentlicht: 2. Juni 2015

© 2015 Ulrich et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Surgical resection, spatial imaging and intraoperative monitoring of brainstem lesions remain a major challenge for neurosurgeons and clinical neuroscientist. Concerning the brainstem, imaging with Diffusion Tensor imaging (DTI) and intraoperative motor evoked potentials (ioMEPs) are demanding to apply. We hypothesize that quantitative data of DTI and ioMEPs could shed light on the linkage between function and structure in brainstem lesions.

Method: DTI and ioMEPs data were analyzed in 14 patients with brainstem lesions. We quantified DTI using fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in regions of interest. In addition we applied ioMEPs (amplitude and velocity) to determine alterations of the CSTs.

Results: Quantification of DTI showed alterations during the pre- and postoperative course. Accordingly, associations between infiltrated CSTs and ioMEPS were demonstrated in certain patients. Reestablishment of the morphological changes in the affected CST postoperatively was associated with a trend for decreasing ADC compared to the pre-operative measurements.

Conclusions: This study forms an excellent foundation for future investigations to evaluate the compatibility of DTI and ioMEPs in brainstem lesion. Our application of DTI and ioMEPs acknowledges the linkage between function and physiology. The distribution of DTI changes and variations in ioMEPs helps neurosurgeons and neurophysiologist to better understand the involvement of the intrinsic brainstem anatomy by pathological processes.