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66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Friendship Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

7. - 10. Juni 2015, Karlsruhe

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Low- and high-grade gliomas resection with intraoperative MRI: a retrospective analysis

Meeting Abstract

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  • Pietro Familiari - Department of Neuroscience, Mental Health and Organ Sense, Unit of Neurosurgery, Faculty of Medicine and Psychology, Sapienza, University of Rome
  • A. Marongiu - Department of Neuroscience, Mental Health and Organ Sense, Unit of Neurosurgery, Faculty of Medicine and Psychology, Sapienza, University of Rome
  • A. Pesce - Department of Neuroscience, Mental Health and Organ Sense, Unit of Neurosurgery, Faculty of Medicine and Psychology, Sapienza, University of Rome
  • Alessandro Frati - Department of Neuroscience, Mental Health and Organ Sense, Unit of Neurosurgery, Faculty of Medicine and Psychology, Sapienza, University of Rome
  • G. D'Andrea - Department of Neuroscience, Mental Health and Organ Sense, Unit of Neurosurgery, Faculty of Medicine and Psychology, Sapienza, University of Rome
  • Antonio Raco - Department of Neuroscience, Mental Health and Organ Sense, Unit of Neurosurgery, Faculty of Medicine and Psychology, Sapienza, University of Rome

Deutsche Gesellschaft für Neurochirurgie. 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Karlsruhe, 07.-10.06.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DocDI.14.02

doi: 10.3205/15dgnc169, urn:nbn:de:0183-15dgnc1693

Veröffentlicht: 2. Juni 2015

© 2015 Familiari et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: The goal of surgery for brain gliomas is to maximize the extent of tumor resection avoiding functional injury. Intraoperative-magnetic resonance imaging (iMRI) has emerged as a procedure to guide their resection.

Method: 92 patients who underwent craniotomy for glioma resection were retrospectively evaluated between March 2009 and March 2013 at Sapienza University of Rome. We compared 50 patients operated without iMRI and 42 patients underwent surgery with iMRI. Volumetric analysis and EOR were performed, using postcontrast T1-weighted images for tumors showing contrast enhancement and T2-weighted images for non enhancing tumors. All patients were operated by the senior author.

Results: For enhancing gliomas, the median EOR increased was 78% (range, 60% - 96%) and 96% (range, 94% - 99%) in patients operated on with and without iMRI respectively. While, the median EOR increased from 72% (range 58% - 86%) in the first group to 90% (range 82% - 98%) in the second group of non enhancing gliomas. The present study reports the progression free survivall (PFS) at 6 months only in 74 patients operated on for high-grade gliomas (III-IV): an increase of 23 % was observed in the cases who underwent further surgery for tumor residual detected by iMRI.

Conclusions: 1.5T intraoperative MRI is a safe technique, and its use optimizes significantly the extent of glioma resection and the overall survivall of the patients.