gms | German Medical Science

59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

01. - 04.06.2008, Würzburg

Infratentorial glioblastoma in adults: Clinical characteristics

Infratentorielles Glioblastom im Erwachsenenalter: Klinische Beobachtungen

Meeting Abstract

  • corresponding author H. Maslehaty - Klinik für Neurochirurgie im Universitätsklinikum Schleswig-Holstein, Campus Kiel
  • A. M. Stark - Klinik für Neurochirurgie im Universitätsklinikum Schleswig-Holstein, Campus Kiel
  • S. Schultka - Klinik für Neurochirurgie im Universitätsklinikum Schleswig-Holstein, Campus Kiel
  • H. M. Mehdorn - Klinik für Neurochirurgie im Universitätsklinikum Schleswig-Holstein, Campus Kiel

Deutsche Gesellschaft für Neurochirurgie. Società Italiana di Neurochirurgia. 59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch). Würzburg, 01.-04.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocP 078

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2008/08dgnc346.shtml

Veröffentlicht: 30. Mai 2008

© 2008 Maslehaty et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Glioblastoma multiforme is the most common and the most malignant intracranial tumor. Infratentorial location is rare in adults. We present five cases of infratentorial glioblastoma, describing clinical presentation, surgical treatment, tumor histology and post-operative course.

Methods: We retrospectively reviewed all patients who underwent biopsy and/or resection for newly diagnosed glioblastoma (WHO grade IV) between January 1991 and June 2007 at our department. Patients of <21 years were excluded. Clinical characteristics and histopathological features were compared between patients with infratentorial and those with supratentorial tumors.

Results: Within these 16 years, a total of 503 patients underwent surgery for glioblastoma. Among them were 5 individuals with infratentorial tumor location (1%). In detail, tumors were located in the bottom of the fourth ventricle (n=1), in the cerebellum (n=2) and in the brainstem (n=2). The mean age was 55.4 years (Range 27 to 80 years). 3 patients were treated by tumor resection whereas 2 patients underwent Stereotactic biopsy only. After the neurosurgical treatment all patients received radiotherapy.

In the case of a 68-year-old woman with gait disturbance and recurrent drop attacks magnetic resonance imaging revealed a tumor at the bottom of the fourth ventricle without signs of hydrocephalus suspective of ependymoma. Tumor resection was performed via a suboccipital approach. Histological examination revealed glioblastoma. In the case of a 80-year-old male patient with gait disturbance since three months, magnetic resonance imaging showed a 2.5cm diameter tumor in the left cerebellar hemisphere suspective of brain metastasis. Total tumor resection was performed, histological examination revealed glioblastoma.

Conclusions: Infratentorial localisation of glioblastoma in adults is rare and can easily be misdiagnosed as brain metastases or even vestibular schwannoma, ependymoma or meningeoma. Surgical treatment is essential for establishing the diagnosis.