gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Animal study of a bioresorbable lumbar interbody fusion cage

Meeting Abstract

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  • corresponding author J.-Y. Lazennec - Department of Orthopaedic Surgery, La Pitié - Salpétrière Hospital, Paris, France
  • A. Madi - Department of Orthopaedic Surgery, La Pitié - Salpétrière Hospital, Paris, France
  • B. Roger - Department of Orthopaedic Surgery, La Pitié - Salpétrière Hospital, Paris, France
  • G. Saillant - Department of Orthopaedic Surgery, La Pitié - Salpétrière Hospital, Paris, France

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc10.05.-02.01

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2005/05dgnc0100.shtml

Veröffentlicht: 4. Mai 2005

© 2005 Lazennec et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

The objective was to evaluate tissue responses after implantation of a lactic acid polymer cage.

Methods

Eighteen lambs underwent anterior lumbar discectomy, followed by cage implantation filled and surrounded with cancellous bone graft. Five groups of three animals were killed, after 3, 6, 9,12 and 24 months, respectively. The entire lumbar spine with surrounding ligaments and muscles was removed for radiographic, MRI, and CT evaluation. Spinal histologic sections stained with Paragon were used to evaluate - bone density and cellularity, - tissue differentiation at the cage-tissue interface, - bone remodeling and healing, - cage resorption and attendant reactions. Bone apposition activity was evaluated by epifluorescence. Surrounding organs and regional lymph nodes were analyzed to evaluate tissue responses.

Results

- After 3 months, active bone formation was noted around the cage, which was nearly intact. - After 6 months, incipient cage resorption and incorporation into bone with increased peripheral bone remodeling were seen, as well as evidence of fusion inside and outside the cage. - After 9 months, fusion with marked bone apposition was evident. The cage showed further resorption, fragmentation, and fibrous infiltration. - Findings after 12 months were established fusion with mineralization of the osteoid in direct contact with the implant, resorption of about 30% of the initial cage surface, and absence of signs of local or systemic intolerance. - After 24 months, fusion was definitively confirmed with more than 60% resorption of the cage surface. No additionnal tissue reaction was observed.

Conclusions

After two years, fusion was achieved inside and outside the cage; there was no local inflammation, necrosis or osteolysis. The bone directly in contact with the cage exhibited structural features similar to those of neighboring tissue.