gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

The biological behaviour of meningiomas in the elderly

Biologisches Verhalten von Meningiomen bei älteren Menschen

Meeting Abstract

Suche in Medline nach

  • corresponding author Florian Roser - Neurochirurgische Klinik, Klinikum Hannover Nordstadt, Hannover
  • M. Nakamura - Neurochirurgische Klinik, Klinikum Hannover Nordstadt, Hannover
  • M. Samii - International Neuroscience Institute, Hannover

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocMI.02.04

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2004/04dgnc0249.shtml

Veröffentlicht: 23. April 2004

© 2004 Roser et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

The biology of tumours in the elderly differs from that of the young. Proliferation, vascularity and hormonal status in meningiomas presumable undergo changes in activity during the age. We try to provide insight into this phenomenon, detailing the immunohistochemical findings in the elderly, compared to younger meningioma patients.

Methods

Among 600 meningiomas from 554 patients examined immunohistochemically using the Mib-1 monoclonal antibody, 64 patients were older than 70 years. Patients with atypical or anaplastic tumours as well as NF-II disease were excluded from statistical analysis to achieve comparable groups. Proliferation index and progesteron-receptor (PR) status of the elderly were compared to the “young” patient group. Clinical charts including surgical records, discharge letters, histological records and imaging studies as well as meticulously focused questionnaires of clinical outcome were reviewed. Correlations with volume-progression of tumour, histological subtype, recurrence-free survival (F/U >34 month), grade of resection, location and osseous involvement were performed as well.

Results

Compared to the “young” group of 443 meningioma patients, the elderly population (mean age 75.8, range 70-94) showed a female: male ratio of 4.2: 1. Mean Ki-67 LI (2.96 %; range 0-15%) and positive PR-status (46%) was significant lower. Total resection (Simpson °I-II) was achieved > 80%, four patients experienced recurrence (6 %, mean time of 20 month). Statistical analysis showed that tumours were larger (mean size on max. ap-diameter 15.1 cm2), less vascularized and showed more intratumoural calcifications.

Conclusions

Meningiomas in the population beyond 70 years differ biologically from the overall group of meningiomas. Less aggressive characteristics account for a slower growth and progression.