gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

In-vivo nuclear magnetic resonance studies for water quantification: Experimental and human applications

Meeting Abstract

  • corresponding author Attila Schwarcz - Department of Neurosurgery at University of Pcs, Pcs /H
  • Z. Berente - Department of Biochemisty at University of Pcs, Pcs /H
  • E. sz - Department of Biochemistry at University of Pcs, Pcs /H
  • J. Pl - Department of Neurosurgery at University of Pcs, Pcs /H
  • F. Kvr - Department of Neurosurgery at University of Pcs, Pcs /H
  • T. Dczi - Department of Neurosurgery at University of Pcs, Pcs /H

Deutsche Gesellschaft fr Neurochirurgie. Ungarische Gesellschaft fr Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft fr Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft fr Neurochirurgie. Kln, 25.-28.04.2004. Dsseldorf, Kln: German Medical Science; 2004. DocJM III.03

Die elektronische Version dieses Artikels ist vollstndig und ist verfgbar unter: http://www.egms.de/de/meetings/dgnc2004/04dgnc0011.shtml

Veröffentlicht: 23. April 2004

© 2004 Schwarcz et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Introduction

Brain oedema is a major clinical problem in more than one third of the neurosurgical cases. In vivo determination of tissue water content (W) is critical to evaluate the effect of the therapy aimed at reducing brain oedema under both experimental and clinical conditions. The aim of our studies was to work out NMR methods suitable for W quantification in brain oedema elicited in rodents as well as to implement fast brain W measuring method in human subjects.

Methods

In the animal studies cold injury was chosen to obtain different W elevations in the brain. Longitudinal relaxation times (T1) were measured at 9.4 Tesla with MRI or MRS and Ws of regions of interest were determined with wet/dry method. T1 values and Ws were correlated to obtain calibration line for in vivo W quantification. In healthy human volunteers T1 and consequent W maps were obtained from the brain at 1 Tesla with a fast MRI method based on turbo-FLASH sequence.

Results

In the animal study strong linear relationship (r = 0.96) was found between T1 values and Ws determined by wet/dry method. In human subjects the applied method was capable of producing accurate T1 and W maps of a given brain slice within 2 min.

Conclusions

In vivo W quantification is feasible in rodents in brain oedema models by means of T1 measurement at high magnetic field. Thus, brain oedema formation and resorption can be followed non-invasively with excellent spatial resolution. The applied T1 and W mapping method in the human brain is suitable for fast evaluation of brain oedema reducing therapy under clinical conditions. The proposed method is widely accessible and does not require special programming skills or high level NMR knowledge for the implementation.