Artikel
Colorectal Schistosomiasis-associated Rectosigmoid Cancer: Biomarkers and Long-term Prognosis
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Autoren
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Hao Feng
- Klinikum Großhadern, Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, München, Deutschland
| Veröffentlicht: | 21. April 2016 |
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Gliederung
Text
Background: This study is to assess the association between the potential long-term effects of previous schistosome infection and rectosigmoid cancer.
Materials and methods: From 11.2006 to 05.2011, 25 patients who had rectosigmoid carcinoma combined with colorectal schistosomiasis (SSC), 217 patients with non-schistosomiasis rectosigmoid carcinoma (NSC), 19 colorectal schistosomiasis(CS) were included. Tumor characteristics, pre-operative investigations, tumor pathological examinations and postoperative course were evaluated.
Results: There was no significant difference in overall survival rate between the SSC and NSC groups. Levels of CEA, AFP and CA19-9 did not differ among three groups, levels of CA-125 were significantly higher (p <0.0001) in CS group. AFP levels were significantly elevated in CS group than in the NSC group, CA19-9 levels were significantly higher in SSC group than those in NSC group. The expression of Bcl-xL, Bad and GFER genes have no significant correlation with schistosome infection.
Conclusion: In summary, Colorectal schistosomiasis was still easily underdiagnosed in patients with or without rectosigmoid carcinoma. Elevated serum CA19-9 and CA-125 may be signals for those who have colorectal lesions and infested water contact history to go through the circumival precipintin test (COPT).
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