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Physical activity and successful aging
10th International EGREPA Conference

European Group for Research into Elderly and Physical Activity

14.09. - 16.09.2006 in Köln

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IGF-I and FGF-2 responses to Wingate anaerobic test in older men

Meeting Abstract

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  • corresponding author R. Amir - Zinman College, Wingate Institute, Israel
  • M. Sagiv - Zinman College, Wingate Institute, Israel
  • D. Ben-Sira - Zinman College, Wingate Institute, Israel
  • M. Sagiv - Zinman College, Wingate Institute, Israel

Physical activity and successful aging. Xth International EGREPA Conference. Cologne, 14.-16.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06pasa055

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/pasa2006/06pasa055.shtml

Published: December 18, 2006

© 2006 Amir et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Reduced activity of the potent anabolic effectors: insulin-like growth factor-I (IGF-I) and fibroblast growth factor-2 (FGF-2), play a role in aging associated muscle loss. The effect of fitness level on IGF-I and FGF-2 responses to all-out anaerobic exercise in older men was studied.

Methods

Twenty four healthy older males: 12 higher fit (58±1y) and 12 lower fit (59±1y) underwent the Wingate anaerobic test. Serum levels of IGF-I and FGF-2 were measured before, immediately after exercise, and 50 min into recovery.

Results

At peak exercise, mean power output and serum lactate were higher (p<0.05) in the higher fit (446.0±14.9 kgm/min for mean ±SD peak power and 12.6±1.1 mml/l for lactate) compared with the lower fit individuals (284.0±6.5 kgm/min and 8.5±0.7 mml/l, respectively). Pre-exercise IGF-I was lower and FGF-2 was higher in the higher fit (335.0±54.0 ng/ml and 1.6±0.1 pg/ml, respectively) compared with lower fit individuals (402.0±50.0 ng/ml and 1.4±0.2 pg/ml, respectively). Following the anaerobic exercise, in both groups, FGF-2 decreased dramatically (p<0.05); in the higher fit individuals FGF-2 level was 0.4±0.1 pg/ml compared to 0.1±0.02 pg/ml in the lower fit individuals. In contrast to FGF-2, IGF-I increased transiently to levels of 405.0±62.0 ng/ml in the higher fit individuals and to levels of 436±57.0 ng/ml in the lower fit individuals. However, the IGF-I elevation was significant (p<0.05) only in the higher fit individuals.

Conclusions

The present study demonstrates that during aging, fitness level can alter circulating levels of IGF-I and FGF-2. Furthermore, fitness level can affect the responses of both mediators to all-out anaerobic exercise.