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29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

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The possible association of an endothelin-1-gen-polymorphism in the promotor region with severe essential hypertension, atherosclerosis and vascular events

Die mögliche Assoziation eines Endothelin-1-Gen-Polymorphismus in der Promotorregion mit schwerer Hypertonie, Atherosklerose und vaskulären Ereignissen

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  • E.G. Schulz - Center of Nephrology and Dialysis Bovenden (Bovenden, D)
  • M. Bargfeldt - Center of Nephrology and Dialysis Bovenden (Bovenden, D)
  • N. Fischer - Center of Nephrology and Dialysis Bovenden (Bovenden, D)
  • A.K. Hesse - University Hospital Göttingen (Göttingen, D)
  • S. Ibrovic - University Hospital Göttingen (Göttingen, D)
  • G.A. Müller - University Hospital Göttingen (Göttingen, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP23

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2005/05hoch023.shtml

Published: August 8, 2006

© 2006 Schulz et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

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Introduction: Endothelin is the most potent endogenous vasoconstrictor and involved in several vascular pathways such as proliferation, aggregation and contractility. Its intense interaction with other vasoactive hormone systems as catecholamines, nitric oxide and cyclooxygenase products revealed the consideration about ET as an interesting candidate gene for the developement of essential hypertension and hypertensive endorgan damages.

Methods: In 400 hypertensive patients and 200 age and gender matched normotensive controls we investigated a Thymine-Guanine-polymorphism at position 1370 by DNA-sequencing. Hypertension was defined as BP > 135/85 mmHg in ABDM (24-h-bloodpressure measurement) or normotension under antihypertensive treatment of minimum 1 drug.

Results: The highest incidence overall demonstrated the TT-genotype (66,9 % of the normotensives; 68,3 % of the hypertensives). Only Hypertensives showed the GG homocygote formation (4 %). Patients with severe hypertension (72,6 %) and vascular events (75 %) presented more often TT. There was no difference with respect to the genotype in patients with or without renal failure. The highest incidence of the GG-formation was detected in patients with severe atherosclerotic vascular damage (16,7 %). The heterocygote formation (TG) showed a similar frequency in all subgroups.

Conclusions: The investigated endothelin gene polymorphism revealed a different vascular risk for both detected homocygote genotypes. Homozygote TT contributes to a higher prevalence of severe hypertension and vascular events whereas the unique GG alteration could be associated with hypertensive vascular atherosclerosis. Thus, the polymorphism at position 1370 could serve as a possibility to differentiate high risk subgroups in the heterogenous population of hypertensive patients.