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79th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

30.04. - 04.05.2008, Bonn

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Chromosome instability in tumour resection margins of oral cancers as a predictor for (loco)regional recurrence

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  • corresponding author Ewa Bergshoeff - Academical Hospital Maastricht, Maastricht, The Netherlands
  • Ernst-Jan M Speel - Department of Molecular Cell Biology, GROW-School for Oncology & Developmental Biology, Maastricht, The Netherlands
  • Johannes J Manni - Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
  • Bernd Kremer - Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Bonn, 30.04.-04.05.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. Doc08hnod475

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hnod2008/08hnod475.shtml

Published: April 22, 2008

© 2008 Bergshoeff et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Introduction: Oral squamous cell carcinoma (OSCC) has a high local recurrence rate, partly related to the presence of potentially malignant (groups of) cells in the resection margins (minimal residual disease). Chromosome instability (CIN) detected in these cells may predict (loco)regional recurrence.

Methods: We followed 20 patients who underwent a radically performed resection of OSCC for 11 years. The tumour resection margins were initially diagnosed as being tumour-free, but 8 out of 20 margins harboured cells with CIN. CIN was indicated by the presence of chromosome imbalances and/or polyploidization for chromosomes 1 and 7 as determined by in situ hybridization.

Results: Whereas 12 out of 20 cases without CIN in the resection margins showed no evidence of disease during follow-up, 2 out of 8 margins with CIN resulted in local recurrence within 5 years of follow up. Furthermore, 2 additional cases with CIN developed a local tumour after 10 years and a locoregional tumour after 11 years, respectively. Four out of 8 cases with CIN did not show tumour recurrences.

Conclusions: Only patients with CIN in tumour resection margins develop a local recurrence within 5 years of follow-up and also (loco)regional tumour outgrowth after up to 11 years of follow-up was seen. These data suggest that detection of CIN can predict (loco)regional recurrence of OSCC.