gms | German Medical Science

104th DOG Annual Meeting

21. - 24.09.2006, Berlin

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Mitomycin-C assisted excimer laser retreatment for corneal haze and regression after myopic PRK – Safety, efficacy and stability at 4-year follow-up

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  • K. Šenková - Department of Pediatric Ophthalmology, Masaryk University Hospital, Brno, Czech Republic
  • R. Autrata - Department of Pediatric Ophthalmology, Masaryk University Hospital, Brno, Czech Republic
  • S. Pyrochtová - Department of Pediatric Ophthalmology, Masaryk University Hospital, Brno, Czech Republic
  • J. Řehurek - Department of Pediatric Ophthalmology, Masaryk University Hospital, Brno, Czech Republic

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogP202

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2006/06dog724.shtml

Published: September 18, 2006

© 2006 Šenková et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective

To assess the efficacy and safety of phototherapeutic keratectomy (PTK) with use of mitomycin C for retreatment of eyes with corneal haze and regression following photorefractive keratectomy (PRK) for medium and high myopia with astigmatism.

Methods

This retrospective study analyzed the refractive and visual results of 63 eyes (51 patients) who were treated by PTK with intraoperative application of 0.02% mitomycin C for corneal haze grade 2 to 3 and myopic regression. These eyes previously undergone PRK for myopia between -6.0 to -11.0 D in the period from January 1998 to November 2002. Retreatment was performed after 9 to 12 months following the inicial PRK procedure in all eyes. Mitomycin C was applied immediately after PTK with soaked microsponge over the ablated stroma for 2 minutes and then the cornea was irrigated with the chilled BSS. Refraction, uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BSCVA) and corneal haze after retreatment were evaluated. All patients were completed 36 to 48 months (the mean 36.3 months) follow-up after retreatment.

Results

The mean BSCVA and UCVA before retreatment was 0.53 and 0.24, respectively. At one year after PTK with mitomycin C, the mean BSCVA and UCVA improved to 0.75 and 0.58 respectively . The mean SE refraction before retreatment was -3.62±2.54 D (range -1.75 to -6.75) and reduced to -1.14±1.35 D (range +0.75 to -2.25D) at final examination. The mean grade of haze before PTK was 2.61 and decreased to 0.35 at 2 years after PTK with mitomycin C (P<0.05). No mitomycin C-related adverse effects and complications were found. The significant improvement of visual acuity was observed in all eyes.

Conclusions

PTK with intraoperative application of diluted mitomycin C 0.02% solution significantly reduced corneal haze and improved visual acuity in patients undergone previous PRK for medium and high myopia complicated by severe haze and regression.