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104th DOG Annual Meeting

21. - 24.09.2006, Berlin

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Systemic risk factors for primary open-angle glaucoma

Generelle Risikofaktoren für primäres Offenwinkelglaukom

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  • S. De Voogd - Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam
  • P. De Jong - Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam
  • N. Jansonius - Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam
  • R. Wolfs - Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam
  • A. Hofman - Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogDO.06.14

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2006/06dog053.shtml

Published: September 18, 2006

© 2006 De Voogd et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

To test our hypotheses that diabetes mellitus, atherosclerosis, or inflammation as determined by serum levels of C reactive protein (CRP) are risk factors for primary open angle glaucoma (POAG).

Methods

In the population-based Rotterdam Study 3837 participants aged 55 years or over were at risk for POAG. At baseline diabetes was defined as the use of anti diabetic medication and/or a random or post load glucose value ≥11.1mmol/l; atheroclerosis was determined by carotid artery echography, abdominal aorta X rays, and ankle-arm index; serum CRP by an immunoassay. Incidence of POAG was defined as absence of (possible) POAG at baseline and presence of probable or definite POAG in at least one eye at follow-up.

Results

After a mean follow-up of 6.5 years 87 (2.3%) participants had incident POAG (iPOAG). Adjusted for age, gender, follow-up time, intraocular pressure, POAG treatment, body mass index and systemic hypertension the relative risk, analyzed in tertiles, of diabetes for iPOAG was 0.65 (95% CI 0.25-1.64), of carotid plaques 1.26 (0.90-1.75), of carotid intima-media thickening 0.86 (0.47-1.57), of aortic calcification 1.02 (0.60-1.75), of a low ankle arm index 0.69 (0.38-1.25), and of the highest CRP level 1.19 (0.68-2.07).

Conclusions

All our hypotheses were falsified and these systemic determinants were no risk factor for POAG.