gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

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Indications and functional results of PDT in patients with choroidal neovascularisation not secondary to age-related macular degeneration

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  • corresponding author M. Schellenbeck - Charité University Medicine Berlin, Campus Virchow, Berlin
  • S. Lechner - Charité University Medicine Berlin, Campus Virchow, Berlin
  • K.-H. Velhagen - Charité University Medicine Berlin, Campus Virchow, Berlin
  • C. Hartmann - Charité University Medicine Berlin, Campus Virchow, Berlin

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.03.13

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2004/04dog189.shtml

Published: September 22, 2004

© 2004 Schellenbeck et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective

The existance of choroidal neovasularisation (CNV) is a common cause of low vision. The development of CNV is a complication of a variety of congenital or acquired ocular disorders. Within the last 4 years, photodynamic therapy (PDT) has been established as a treatment option in patients with CNV secondary to age-related macular degeneration. The objective of this study was to evaluate the outcome and functional results of PDT with verteporfin in patients with not age-related CNV.

Methods

In all cases, PDT was performed as standart PDT without complications. Re-treatments were performed after 3 months. Indications for re-treatments were fluorescein leakage and intraretinal edema. Within the last 3 years, a total of 52 patients received PDT for CNV secondary to pathologic myopia, traumatic CNV, inflammatory CNV, idiopathic CNV, autosomal dominat drusen, retinal teleangiectasia and presumed ocular histoplasmosis syndrom (POHS).

Results

The mean follow-up time is 18.7 months, the mean age of the patients is 37.6 years. An average of 2.3 treatments were performed. 41 out of 47 patients (87.2%) have been stabilized in visual acuitiy and lost 3 or less lines of visual acuity. 22 patients (46.8%) have improved in visual acuity (1 or more lines) and 14 patients had moderate vision loss of 3 or more lines. No clinically relevant side effects or complications were observed.

Conclusions

PDT with verteporfin is a safe and effective treatment option for CNV not secondary to age-related macular degeneration. A majority of patients in this study achieved stabilization of vision after PDT. Still the treatment of CNV remains a challenging problem in ophthalmology.