Article
Different multifocal intraocular lenses – effect on lens epithelial cells in vitro on human capsular bags
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Published: | September 22, 2004 |
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Outline
Text
Objective
To investigate the effect of the posterior surface structure in different multifocal intraocular lenses (MIOL) on lens epithelial cells (LEC) in vitro on a human capsular bag model.
Methods
Sham cataract surgery, including IOL-into-the-bag-implantation, was performed on 18 donor eyes after removal of the cornea. The capsular bag including the IOL was dissected free, pinned on a culture dish, covered with medium and incubated. In each pair of donor eyes one eye had a diffractive PMMA IOL (811E, Pharmacia), the other eye had a refractive PMMA IOL (PA154N, Allergan) implanted, both IOLs with rounded edges. The time until the posterior capsule was totally covered by a confluent monolayer of LECs was documented.
Results
Posterior capsule was totally covered by a confluent monolayer of LEC on average at day 16.4 (±4.2) in the capsular bags with a diffractive MIOL, and at day 16.3 (±3.2) with a refractive MIOL. The difference is not statistically significant.
Conclusions
Although the two compared MIOL models have differently structured posterior surfaces, we could not observe a difference in LEC growing. Other factors, e.g. optic edge, seem more important in terms of PCO. A difference in secondary cataract might not be of any concern having the choice between those two MIOL models.