gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

Article

Send article

Therapy-induced tumor regression in adult soft tissue sarcomas

Meeting Abstract

Search Medline for

  • corresponding author presenting/speaker Marcus Lehnhardt - Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Referenzzentrum für Gliedmaßentumore, BG-Klinik Bergmannsheil Bochum, Ruhr Universität Bochum, Deutschland
  • Adrien Daigeler - Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Referenzzentrum für Gliedmaßentumore, BG-Klinik Bergmannsheil Bochum, Ruhr Universität Bochum
  • Hans Steinau - Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Referenzzentrum für Gliedmaßentumore, BG-Klinik Bergmannsheil Bochum, Ruhr Universität Bochum
  • Andrea Tannapfel - Institut für Pathologie, Ruhr Universität Bochum
  • Cornelius Kuhnen - Institut für Pathologie, Ruhr Universität Bochum

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO630

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dkk2006/06dkk738.shtml

Published: March 20, 2006

© 2006 Lehnhardt et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Morphological findings of 21 soft tissue sar-comas of adulthood following preoperative chemo- and/or radiotherapy including per-fusion therapy and resection are present-ed. The therapy-induced changes included a spectrum ranging from total tumor regres-sion up to still completely vital tumor (medi-an of all cases: 30% vital tumor tissue). 7 of 21 sarcomas (33%) were evaluated as responders (grade I–III). So-called malig-nant fibrous histiocytoma (MFH) revealed a good tumor response to preoperatively ad-ministered therapy (regression grades I and II). Myxoid/round-cell liposarcoma exhibit-ed regression grades of IV–V (i.e. 30% up to 95% vital tumor tissue, non-responders). Sy-novial sarcoma was characterized by regres-sion grades III up to VI (i.e. up to 100% vi-tal tumor tissue without any signs of regres-sion, 83% non-responders). Completely vi-tal tumor was evident in 2 synovial sarco-mas despite preoperative tumor therapy. These findings hint towards differences in response of distinct sarcoma entities to preoperative chemo-/radiotherapy. A grad-ing of therapy-induced tumor regression in adult soft tissue sarcomas may best re-fer to already established grading schemes (e.g. according to the grading scheme for osteosarcomas following chemotherapy of Salzer-Kuntschik). A report of sarcoma re-section specimens should include the per-centage of vital tumor tissue.