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27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

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Biochemical Monitoring of Free Radicals, Growth Factors, Receptors and Steroids in cases of Breast Cancer under Chemotherapy

Meeting Abstract

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  • corresponding author presenting/speaker Steffen Albrecht - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden, Deutschland
  • Kristin Eckardt - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden
  • Steffen Albrecht - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden
  • Wolfgang Distler - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPE098

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dkk2006/06dkk208.shtml

Published: March 20, 2006

© 2006 Albrecht et al.
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Outline

Text

Free radicals play an important role within the tumour genesis as well as within the physiological immune defence. The survey was aimed at finding out whether the concentration of rective oxygen species (ROS) in patients with breast carcinoma is influenced by means of chemotherapy to what degree. A second question was whether it can serve as a prognostic factor.

At 60 breast carcinoma patients the ROS [O2-*], [OH*], [H2O2]was determined by means of chemiluminescence directly after diagnosis of the desease and was compared with tumour free probands. Besides, the ROS was measured between and after the infusion of epirubicin/ cyclophosphamid (EC) and epirubicin/ taxol (ET). Simultaneously, NO, DHEA-S, Androstendion, fTestosteron, Testosteron, CA 15-3, CA 125, sVCAM-1, CD62E, sIL-2R was determined. The influence of clinical and anamnestic factors was surveyed on the determined parameters.

Within patients with breast carcinoma [O2 -*] was significantly degraded. After EC, the [OH*], [H2O2] were droped and the functional capacity of phagocytosis was significantly increased. A decrease of [O2 -*], [OH*], [H2O2] and their functional capacity of pagocytosis was generally measured after exposure to ET. While chemotherapy, the ROS was correlated with clinical and anamnestic factors. There was no influence of the concentration of NO, DHEA-S, Androstendion, fTestosteron, Testosteron, CA 15-3, CA 125, sVCAM-1, CD62E, sIL-2R by the administered chemotherapy and these concentrations were not correlated with the height of the ROS.

These parameters still depended on the clinical and anamnestic factors. The ROS was influenced by interactions of several systems. The importance of one single parameter could only estimated. The patient´s medical condition has to considered to draw conclusions from the ROS for the prognosis and the development of the breast carcinoma.