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27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

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Polymorphism of the ATM-gene seems to have no major impact on the risk for a breast cancer disease

Meeting Abstract

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  • corresponding author presenting/speaker Peter A. Fasching - Frauenklinik des Universitätsklinikums Erlangen, Deutschland
  • Stefanie Frank - Frauenklinik des Universitätsklinikums Erlangen
  • Michael Schrauder - Frauenklinik des Universitätsklinikums Erlangen
  • Christian Löhberg - Frauenklinik des Universitätsklinikums Erlangen
  • Michael Lux - Frauenklinik des Universitätsklinikums Erlangen
  • Reiner Strick - Frauenklinik des Universitätsklinikums Erlangen
  • Matthias W. Beckmann - Frauenklinik des Universitätsklinikums Erlangen
  • Pamela Strissel - Frauenklinik des Universitätsklinikums Erlangen

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPE093

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dkk2006/06dkk203.shtml

Published: March 20, 2006

© 2006 Fasching et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Introduction: The ATM-Gene plays a key role in DNA-repair and several models of carcinogenesis. The ATM-product interacts with several oncogenic and tumor-suppressive proteins like p53, Rb, E2F or cyclines. A genetic variation at the gene encoding for ATM may be associated with an altered breast cancer risk. Aim of this study was to assess the association of ATM-polymorphisms with the risk for a breast cancer disease.

Methods: Subjects were obtained from the Erlangen Breast Cancer Association Study Subjects were 196 histologically confirmed breast cancer patients and 385 non-hospital controls without cancer. Polymorphism d1853v (rs1801673) of the ATM-gene was analyzed by RT-PCR with the ABIPrism7000®. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by logistic regression analysis.

Results: The frequency among controls was 73,0% for the A/A genotype, 26% for the A/T genotype and 1% for the T/T genotype. The breast cancer cases showed an a distribution of 73% (A/A), 25,5% (A/T) and 1,5% (T/T). No association was found for each genotype (p=0,875).

Conclusion: In our study no association between breast cancer risk and a polymorphism of the ATM-gene could be found. Concerning the rare T/T genotype there was a non-significant increase for the breast cancer risk. The complete analysis of the whole sample (n=985) of the Erlangen Breast Cancer Association Study will be presented at the congress.