Article
Changes in aqueductal CSF stroke volume and the progression of symptoms in unshunted idiopathic NPH patients
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Published: | May 30, 2008 |
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Objective: Idiopathic normal pressure hydrocephalus (iNPH) represents a diagnostic challenge, given its variable presentation and progression, and Stroke Volume (SV), defined as the mean volume of Cerebro-Spinal Fluid (CSF) passing through the aqueduct during both systole and diastole, greater than or equal to 42 microliters serves as a selection criteria for patients with good probabilities of improvement after Ventriculo-Peritoneal Shunting (VPS). In our study we evaluated the SV changes during the progression of the clinical symptoms in patients with suspect of NPH.
Methods: Nine patients who presented with clinical and radiologic evidence of NPH, but refused treatment with VPS, were evaluated every six months for up to two years for progression in their clinical symptoms and changes in their SV, as measured by Phase Contrast Cine-MR (PCCMR).
Results: SV appears to increase between the onset of the symptoms and the following 18–20 months, then appears to plateau, following in the next 18–20 months by a slight decline to then drop more precipitously in the next 12 months. During this time, however, the patient’s clinical symptoms progressively worsen.
Conclusions: Patients with a low SV have not necessarily had brain atrophy and can show, in the following months, a progressive increase in SV which qualifies them as good candidates for VPS. The progressive reduction of the SV in untreated patients with worsening clinical symptoms may be a sign of a progressive cerebral ischemic injury which renders the NPH irreversible.