gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

Article

Send article

Spinal malignant gliomas in adults

Spinale maligne Gliome des Erwachsenenalters

Meeting Abstract

Search Medline for

  • corresponding author Y. Mondorf - Neurochirurgische Klinik, Nordstadtkrankenhaus Hannover
  • T. Kapapa - Neurochirurgische Klinik, Universitätsklinikum Ulm
  • E. Rickels - Neurochirurgische Klinik, Universitätsklinikum Ulm
  • D. H. Woischneck - Neurochirurgische Klinik, Universitätsklinikum Ulm

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocP 038

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2007/07dgnc293.shtml

Published: April 11, 2007

© 2007 Mondorf et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective: Glioblastomas are the most common type of brain tumors; astrocytic in their origin, they are anaplastic tumors, and are located mainly in the cerebral hemispheres. Intraspinal highgrade gliomas, which are often described in children, are rare. To the authors' knowledge, little information has been published to date regarding the total occurence and the prognostic impact of clinicopathologic factors. Presents of structured and consentient therapy is not given.

Methods: The clinical course of three patients in age of 21, 61 and 71 years is described. Outcome was compared according to Glasgow-Outcome-Scale, localization, initial therapy and after-treatment (radiation vs. chemotherapy).

Results: Initial symptoms are represented by lumboischialgia, dys- and hypaesthesia as well as ataxia and strong constipation. Diagnostics like MRI or computed tomography displayed intraspinal tumors in cervical (n=2) and thoracic (n=1) spinal cord.

Patients gained laminectomy (n=2) or hemilaminectomy with massreduction of the tumor (n=3) and myelotomy (n=1). Histological preparation revealed malign gliomas like glioblastoma (n=2) and malign astrocytoma WHO Grade III. After initial surgery, 1 patient was treated with radiation therapy alone and 2 received radiation therapy with chemotherapy. Patterns of disease recurrence included, zerebral metastases (n=1), local extension (n=1), and diffuse spread along the neuraxis (n=1). There are two survivors after eight and two month.

Conclusions: The elderly Patient had a shorter survival period compared with younger patients. Patients with combined radiation and chemotherapy had longer survival.