gms | German Medical Science

57th Annual Meeting of the German Society of Neurosurgery
Joint Meeting with the Japanese Neurosurgical Society

German Society of Neurosurgery (DGNC)

11 - 14 May, Essen

Does the SERPINA3 gene play a role in the formation of intracranial aneurysms?

Spielt das SERPINA3-Gen eine Rolle bei der Bildung intrakranieller Aneurysmen?

Meeting Abstract

  • corresponding author B. Krischek - Neurochirurgische Klinik, Philipps Universitätsklinikum Marburg, Germany
  • T. Dukatz - Neurochirurgische Klinik, Philipps Universitätsklinikum Marburg, Germany
  • H. Kasuya - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University
  • H. Akagawa - Division of Genetic Diagnosis, Institue of Medical Science, The University of Tokyo
  • I. Inoue - Division of Genetic Diagnosis, Institue of Medical Science, The University of Tokyo
  • T. Hori - Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University
  • H. Bertalanffy - Neurochirurgische Klinik, Philipps Universitätsklinikum Marburg, Germany

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocFR.10.01

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2006/06dgnc059.shtml

Published: May 8, 2006

© 2006 Krischek et al.
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Outline

Text

Objective: The member 3 of clade A of serine proteinase inhibitors (SERPINA 3) regulates the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In previous studies, there was evidence that a polymorphism in the SERPINA3 gene was associated with intracranial aneurysms (IA) found in a Polish population as well as in cases of hemorrhagic stroke in Spanish patients. We performed a case/control study to determine whether this A/T polymorphism was associated with IA in Japanese patients.

Methods: 438 patients with intracranial aneurysms and 395 control cases of Japanese origin were genotyped for the SERPINA3 A/T polymorphism. By using a polymerase chain reaction and genotyping through direct sequencing in genomic DNA, we detected the SERPINA3 polymorphism.

Results: In 438 patients with intracranial aneurysms the SERPINA3 genotype distribution did not differ significantly from controls.

Conclusions: In the Japanese population, the A/T polymorphism of the SERPINA3 gene is not associated with intracranial aneurysms.