gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

Isoprostane and cerebral metabolism after aneurysmal subarachnoid hemorrhage in humans – A preliminary experience

Isoprostan und der zerebrale Metabolismus nach aneurysmatischer Subarachnoidalblutung des Menschen – vorläufige Ergebnisse

Meeting Abstract

  • corresponding author Matthias Oertel - Neurochirurgische Klinik, Universitätsklinikum Gießen, Gießen
  • W. Deinsberger - Neurochirurgische Klinik, Universitätsklinikum Gießen, Gießen
  • R. Babakhanlou - Neurochirurgische Klinik, Universitätsklinikum Gießen, Gießen
  • D.-K. Böker - Neurochirurgische Klinik, Universitätsklinikum Gießen, Gießen

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 07.74

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0357.shtml

Published: April 23, 2004

© 2004 Oertel et al.
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Outline

Text

Objective

8-Epi-Prostaglandin F (Isoprostane) is a product of the non-enzymatic radical induced breakdown of arachnoidonic acid. As shown in animal models, it has effects on cerebral metabolism. The purpose of this study has been to test the hypothesis that isoprostane influences cerebral metabolism after subarachnoid hemorrhage (SAH) in humans.

Methods

A total of 21 studies were performed on 5 SAH patients (age 47±5 years, Hunt and Hess 4). Until day 10 Isoprostane was measured in arterial, jugular-venous blood samples and cerebrospinal fluid (CSF). In addition arterio-venous difference for oxygen (avDO2) and glucose (avDGlc) were evaluated. Metabolic ratio (MR=avDO2/avDGlc) was calculated to estimate cerebral metabolism. Relative hyperglycolysis was defined as MR less than 0.6.

Results

On the average, isoprostane concentrations were higher in arterial than in jugular-venous blood and CSF 165.9±142 pg/l, 113.6±69.3 pg/l and 63.6±28 pg/l, respectively. Mean avDO2 and avDGlc was 3.2±1.6 Vol% and 5.6±7.4 mg%. In 71% of studies Isoprostan concentrations were higher in arterial than in jugular-venous blood. There was a statistical trend for arterial isoprostane and avDO2 (p=0.08) Relative hyperglycolysis was seen in 53% of studies where isoprostane was higher than in studies with normal MR.

Conclusions

Isoprostane seems to influence cerebral metabolism. Most interestingly, it is likely to be generated in other organs than the brain.