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55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

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Oligodendroglial tumors: Refinement of candidate regions on chromosome arm 1p and correlation of 1p/19q status with survival

Oligodendrogliale Tumoren: Verfeinerung der Kandidatenregion auf Chromosom Arm 1p und Korrelation des 1p/19q Status mit dem Überleben

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  • corresponding author Jörg Felsberg - Institut für Neuropathologie, Heinrich-Heine-Universität, Düsseldorf; Institut für Neuropathologie, Rheinische-Friedrich-Wilhelms-Universität, Bonn
  • A. Erkwoh - Neurochirurgische Klinik, Rheinische-Friedrich-Wilhelms-Universität, Bonn
  • M. C. Sabel - Klinik für Neurochirurgie, Heinrich-Heine-Universität, Düsseldorf
  • L. Kirsch - Neurochirurgische Klinik, Evangelisches-Johanniter-Klinikum, Duisburg
  • R. Fimmers - Abteilung Biometrik, Informatik und Epidemiologie, Rheinische-Friedrich-Wilhelms-Universität, Bonn
  • B. Blaschke - Institut für Neuropathologie, Heinrich-Heine-Universität, Düsseldorf
  • U. Schlegel - Neurologische Klinik, Rheinische-Friedrich-Wilhelms-Universität, Bonn
  • J. Schramm - Neurochirurgische Klinik, Rheinische-Friedrich-Wilhelms-Universität, Bonn
  • O. D. Wiestler - Institut für Neuropathologie, Rheinische-Friedrich-Wilhelms-Universität, Bonn
  • G. Reifenberger - Institut für Neuropathologie, Heinrich-Heine-Universität, Düsseldorf

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 06.59

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0342.shtml

Published: April 23, 2004

© 2004 Felsberg et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Loss of heterozygosity (LOH) on the chromosome arms 1p and 19q is frequent in oligodendroglial tumors and has been correlated with chemosensitivity and good prognosis in anaplastic oligodendrogliomas. The oligodendroglioma-associated tumor suppressor genes on 1p and 19q are as yet unknown.

Methods

To narrow down candidate regions on 1p, we investigated oligodendroglial tumors from 89 patients for LOH at up to 30 polymorphic loci on 1p. In addition, all tumors were studied for LOH at 7 loci on 19q.

Results

Combined LOH on 1p and 19q was detected in 20/24 oligodendrogliomas (83%), 15/24 anaplastic oligodendrogliomas (63%), 10/18 oligoastrocytomas (56%), and 12/23 anaplastic oligoastrocytomas (52%). Five tumors demonstrated partial deletions on 1p, which makes is possible to define three distinct candidate regions at 1p36.31-pter distal to D1S2633, 1p36.22-p36.31 between D1S489 and D1S2642, and 1p34.2-p36.1 between D1S2743 and D1S482, respectively. No partial deletions were detected on 19q. Combined LOH on 1p and 19q was associated with prolonged time to progression and longer overall survival, in particular in patients with anaplastic tumors.

Conclusions

Our results refine the location of putative oligodendroglioma suppressor genes on 1p and support the significance of LOH on 1p and 19q as a favorable prognostic marker.