Artikel
Epidemiology of primary bone cancers in Denmark since 1943
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Veröffentlicht: | 19. Oktober 2004 |
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Gliederung
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Introduction
To investigate time trends in incidence and distribution of bone cancer in Denmark since 1943.
Methods
All cases with primary bone cancer were extracted from the Danish Cancer Registry (1943 - 99). Data on morphology were available since 1978. Univariate descriptive statistics and linear regression of the number of new cases on year of diagnosis and age were calculated.
Results
2406 cases were included in the analysis (90 %). The age-distribution was bimodal with peaks at 20 - 24 years and 70 - 79 years. The number of new cases decreased by 3.4/2.9 cases (m/f) every 5 years, with an overall reduction in the number of new cases of 73%/70% (m/f) . However, in young persons (<30 years) the number of new cases did not decrease. Most common were osteosarcomas (38% of all histologically proven cases) with an average increase of 2.4 cases per interval. The number of new cases of chondrosarcoma (35% of proven cases, predominantly in the elderly) and Ewing's sarcoma (15% of proven cases) decreased. 72% of cases were localized, 10% had regional spread and 18% distant metastases. The number of new cases of distant spread decreased strongly by 5.2 cases every 5 years (R2=0.91). In 1963-67, 25% had distant metastases, and only 10,5 % in 1993-99.
Conclusions
Bone cancer showed a steady, but slow decrease in the number of new cases, but only for people > 29 yr. The number of new cases of osteosarcoma increased slowly. The number of new cases with distant matastasis decreased strongly through the period, perhaps due to better surveillance and earlier detection.