Figure 2. In vivo bioimaging for the SDF-1α/CXCR4 pathway induced Luc-MSCs migration. Silicone expanders were implanted in the backs of rats. Regular saline injections were administered in the MSC Group and the AMD-MSC Group but not in the Control Group. Luc-MSCs were transplanted via the retrobulbar venous plexus in rats from the MSC Group and the Control Group, while rats from the AMD-MSC Group were treated with AMD-3100 pretreated Luc-BMSCs (AMD-3100-BMSCs). The Luc-BMSC signal was observed in mechanically stretched skin on D7 in the MSC Group (A). MSC migration was not observed in either the AMD-MSC Group (B) or the Control Group (C). The time course of luminescence is depicted. The MSC Group had significantly higher luminescence in the expanded skin than the AMD-MSC Group and the Control Group (*p<0.05).