Figure 1: COX-2 and NLRP3 expressions in AVMs: Immunohistochemical (IHC)-stainings (left images: x4 magnification; right images: x40 magnification) with cyclooxygenase 2 (COX-2 A-C 1+2) and pyrin domain-containing protein 3 (NLRP3, A-C 3+4) antibodies of arteriovenous malformations (AVMs). In all AVMs, an average of 55.19% of cells are positive for NLRP3. At the same time, only an average of 4.71% of cells are positive for COX-2.