Figure 1: Specification of eligibility criteria in Protégé [36] (excerpt)
(A) Ontology tree: subclasses of Single_Phenotype are NSiP classes (e.g., Age_IC); their subclasses are RSiP classes (e.g., Age_IC_s_ge_40_l_66). (B) Specification of value range restrictions as anonymous equivalent classes of RSiP classes. The gender is restricted using the code ‘male’ from the FHIR value set ‘administrative gender’. (C) Example annotations of NSiP classes (e.g., code, data type, title, resource type, measurement unit, validity period).