Figure 1: Crosstalk between Wnt/ß-catenin and MAPK signaling in cancer. In colon cancer, stimulation of Wnt/ß-catenin signaling (left) inhibits the activity of the destruction complex, indicated by the scaffold proteins Axin and APC and the kinase GSK3, leading to Ras stabilization and consequent activation of the downstream MAPK signaling cascade (right). In melanoma, increased MAPK signaling stabilizes Axin, which inhibits Wnt signaling. RTK, receptor tyrosine kinase.
[Credit: Y. Hammond, American Association for the Advancement of Science]