Figure 3: TGFβ depletion does not alter pro-inflammatory cytokine/chemokine production, peritoneal composition of monocytes, neutrophils and eosinophils during SIRS and their expansion in L. sigmodontis-infected mice.
(A) Serum and (B) peritoneal cytokine/chemokine levels six hours after E. coli injection. (C,D) Relative and absolute number of peritoneal CD11b+Ly6G–Ly6C++ monocytes, (E,F) CD11b+Ly6G+Ly6C+ neutrophils and CD11b+F4/80medSiglecF+ eosinophils (G,H) six hours after E. coli injection in mice that were infected for 90 days with L. sigmodontis and uninfected controls and received either anti-TGFβ or an isotype control before E. coli challenge. Data represent three pooled independent experiments with at least six mice per group. Data are shown as mean +SEM (A,B) and median (C–H) and was tested for statistical significance by Kruskal-Wallis test and Dunn’s Multiple Comparison post hoc test.