gms | German Medical Science

Figure

Figure 2: Carcinogenesis during exposition with carcinogenic agents, e.g. smoking: Accumulation of genetic alterations leads to a loss of cell cycle control and unimpeded growth (left). During HPV-induced Carcinogenesis (right) the sentinel of cell cycle, the p53-protein, is knocked down by viral E6- and E7-proteins. This process is advanced by integration of viral DNA. Both pathways may overlap.