gms | German Medical Science

Figure

Figure 3: HPV-unrelated carcinogenesis (A): p16 is not activated and phosphorylation of Rb is unblocked. Progression of cell cycle is not inhibited by mutated p53 and apoptosis cannot be initiated. HPV-related carcinogenesis (B): Binding of E7 to pRB leads to activation of E2F, which induces cell cycle progression and induces p16-expression. E6-protein is responsible for degradation of p53. The attendance of noxious agents for HPV-related carcinogenesis is not mandatory, however might occur in addition.