Figure 8: Macroscopical findings in the abdominal cavity after application of Poly-L-Lactid (A) or Copolymer (B) in the gastric wall of rats
After 1 week of implantation time after application Poly-L-Lactid (A) in the gastric wall distinctive adhesions of the whole abdominal cavity were found. The animal experiments with Poly-L-Lactid had to be terminated after 12 animals because of perforation of the gastric wall and serious pertonitis in 75% of the animals. In contrast to these findings a mirroring peritoneum was detected in all animals of the implantation group (n=42) after reconstruction of the gastric wall by the Copolymer without adhesions of the intestinal loops. Gastrointestinal complications like perforation or peritonitis did not occur in any one of the animals of the implantation group.