Figure 12: During phagocytosis, intracellular reactive oxygen species rapidly increase, known as oxidative burst.
Following receptor binding od , e.g. LPS, and particle internalization, the protein p47phox is activated and integrates with the additional components p67phox and p40phox into the phagosome membrane, where it combines with flavocytochorme b to the active NADPH-oxidase complex. This enzyme complex catalyzes the generation of ROS and protons, which shift through proton-channels into the interior of the phagosome, where they destroy the internalized particle.