Figure 1: Top right: image processing pipeline based on PHT, Bottom: (a-d) brain MRI of an MS patient: a) original FLAIR image, b) preprocessed, c) MS lesions by the ML model, d) MS lesions delineated by a human expert, and (e, f) brain MRI of an LD patient: e) original FLAIR image, f) preprocessed. The table reports the metrics for evaluating the model applied to MS data.