gms | German Medical Science

25th Annual Meeting of the German Retina Society

German Retina Society

01.06. - 02.06.2012, Münster

Structure-function correlation in macular telangiectasia type 2: a longitudinal study

Meeting Abstract

  • Frank G. Holz - Universitäts-Augenklinik Bonn
  • T. Heeren - Universitäts-Augenklinik Bonn
  • S. Baumüller - Universitäts-Augenklinik Bonn
  • T. Clemons - The EMMES Corporation, Rockville, USA
  • P. Charbel Issa - Universitäts-Augenklinik Bonn

German Retina Society. 25th Annual Conference of the German Retina Society. Münster, 01.-02.06.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12rg17

doi: 10.3205/12rg17, urn:nbn:de:0183-12rg173

This is the translated version of the article.
The original version can be found at:

Published: May 30, 2012

© 2012 Holz et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Purpose: Recent findings indicate that besides the vascular changes a neurodegenerative process contributes to the pathogenesis of macular telangiektasia type 2 with paracentral scotomata in presence of preserved central visual acuity. These scotoma can be accurately identified by fundus-controlled microperimetry. In this study progression of these scotoma was analysed using microperimetry and correlated with BCVA and SD-OCT findings.

Methods: In a prospective longitudinal study 78 eyes of 40 patients were examined over a time period of 47±14 months. Distance between microperimetry test points was 1 degree. BCVA was determined using ETDRS charts. SD-OCT images were obtained with the Spectralis HRA-OCT.

Results: 27 of 31 (87%) eyes with preexisting absolute scotoma as opposed to 12 of 47 (25%) of eyes without scotoma at baseline developed at least one additional absolute scotoma. A central visual acuity loss of ≥2 lines occurred in only 23% and 28% of eyes, respectively. On average 1.0±0.88 and 0,27±0.75 new absolute scotoma developed per year. New scotoma were associated with a well-defined loss of the photorecptor layer and a thinning of the neurosensory retina. Alterations in inner retinal layers, i.e. cystoid cavities, showed no topographic association with absolute scotoma.

Conclusions: The results indicate that central visual acuity ist not suitable for assessing the progression of MacTel 2. Microperimetry is more sensitive for detection of progression of functional impairment because of the typical paracentral loss of photoreceptors.Therefore, microperimetry appears suitable as an outcome parameter in future prospective interventional trials.