gms | German Medical Science

24th Annual Meeting of the German Retina Society

German Retina Society

17.06. - 18.06.2011, Aachen

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Late-Onset Stargardt disease

Meeting Abstract

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  • Carel B. Hoyng - Department of Ophthalmology, Radboud University Nijmegen
  • A. den Hollander - Department of Ophthalmology, Radboud University Nijmegen
  • C. Boon - Department of Ophthalmology, Radboud University Nijmegen

German Retina Society. 24th Annual Conference of the German Retina Society. Aachen, 17.-18.06.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11rg04

doi: 10.3205/11rg04, urn:nbn:de:0183-11rg049

This is the English version of the article.
The German version can be found at: http://www.egms.de/de/meetings/rg2011/11rg04.shtml

Published: June 15, 2011

© 2011 Hoyng et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Background: About 10% of dry age-related macular degeneration may be caused by mutations.

Methods: We reviewed the charts of 19 patients, originally diagnosed with dry AMD, and in whom because of suspect funduscopic alterations, mutation analysis of the ABCA4 gene was performed.

Results: The mean age of onset of visual complaits was 55 years. In 85% of eyes flecks and in 70% geographic atrophy was found. In 75% a dark choroid was found in fluorescein angiography. In all patients mutations in the ABCA4 gene were found.

Conclusion: It is important to differentiate Late-onset Sargardt disease from dry AMD. With respect to nutrition (vitamine A) and exposure to sunlight these patients need different advices.