gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Risk evaluation in patients with acute non-arteriitic central retinal artery occlusion

Meeting Abstract

  • Nicolas Feltgen - University Eye Clinic Göttingen
  • A. Pielen - University Eye Clinic Freiburg i. Br.
  • B. Junker - University Eye Clinic Freiburg i. Br.
  • A. Wolf - University Eye Clinic Würzburg
  • B. Jurklies - University Eye Clinic Essen
  • K. Kampik - University Eye Clinic Würzburg
  • S. Pantenburg - University Eye Clinic Göttingen
  • EAGLE-Studiengruppe

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg74

doi: 10.3205/10rg74, urn:nbn:de:0183-10rg742

This is the translated version of the article.
The original version can be found at:

Published: September 21, 2010

© 2010 Feltgen et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background and Purpose: To prospectively evaluate cardio-vascular risk factors in a well defined group of patients suffering from acute central retinal artery occlusion (CRAO) not older than 20 hours.

Methods: As part of the European Assessment Group for Lysis in the Eye (EAGLE) trial the data of 84 patients were analyzed. In this study intraarterial fibrinolysis was compared to a non-interventional therapy in patients with an acute CRAO not older than 20 hours. Pre-existing diseases and risk factors were collected at the time of inclusion. Detailed neurologic and cardiologic examination was performed after initial therapy to establish the cause of the occlusion. Amongst others patients were investigated by echocardiography, sonography of extracranial arteries, and laboratory parameters.

Results: Known pre-existing risk factors were elevated blood pressure (n=42/58%), stenosis of the carotid arteries (n=2/3%), hypercholesterolemia (n=5/7%), cigarette smoking (n=32/45%), heart failure like arrhythmia (n=4/6%), and cardiac valvula diseases (n=5/7%). New diagnosed risk factors were elevated blood pressure in 12 patients (17%), stenosis of the carotid arteries (n=29/40%), hypercholesterolemia (n=24/33%), heart failure like arrhythmia (n=5/7%), ischemic stroke (n=1/1%), haemorrhagic stroke (n=238%), and cardiac valvular diseases (n=17/24%). The highest correlation between CRAO and new identified risk factors was found for ipsilateral carotid artery stenosis.

Conclusions: Sonography of the extracranial arteries and echocardiography are the most important instrument to evaluate patients' cardiovascular risk during a neurologic and cardiologic examination and must be recommended for all patients after acute CRAO.